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Survival after intracranial inoculation of weanling rats with 666 CFU of C. neoformans. Mice were treated orally once daily (LY295337, 100 [LY 100] or 200 [LY 200] mg/kg/day) or intraperitoneally once daily (amphotericin B, 6 mg/kg/day [AMB 6]). LY 200 was superior to the control (P = 0.03) and LY 100 (P = 0.001). LY 100 was not superior to the control (P = 0.3). AMB 6 was not superior to the control (P = 0.15, Wilcoxon test).
