FIG. 2.

CFU of C. neoformans per gram of brain measured at 12 days after infection and treatment days 2 through 10. Mice were treated once daily with LY295337 orally at 200 mg/kg (LY200, n = 13) or 100 mg/kg (LY100, n = 7), amphotericin B intraperitoneally at 6 mg/kg (AmB, n = 6), or fluconazole at 30 mg/kg (Flu, n = 7). All regimens but LY100 reduced fungal brain tissue counts significantly below controls (Con) (P < 0.05, Dunnett’s one-tailed t test).