Table 4.
Hazard ratios for overall survival.
| Variables | aHR | 95% CI | p-Value | |
|---|---|---|---|---|
| CAEs within One Year after ICI Initiation (ref = No) | 1.46 | 1.26 | 1.70 | 0.000 |
| Age at ICI Initiation (ref = 18–44 years) | ||||
| 45–54 years | 0.94 | 0.78 | 1.14 | 0.540 |
| 55–64 years | 0.95 | 0.80 | 1.12 | 0.537 |
| 65–74 years | 0.96 | 0.81 | 1.14 | 0.631 |
| 75 years or older | 1.00 | 0.83 | 1.21 | 0.995 |
| Sex (ref = Female) | ||||
| Male | 0.99 | 0.91 | 1.08 | 0.839 |
| Race (ref = White) | ||||
| Black | 0.69 | 0.57 | 0.84 | 0.000 |
| Other | 0.82 | 0.57 | 1.19 | 0.299 |
| Unknown | 1.11 | 0.86 | 1.43 | 0.436 |
| Hispanic (ref = No) | 1.04 | 0.78 | 1.39 | 0.778 |
| Charlson Comorbidity Index (ref = 0) 1 | ||||
| 1 | 1.40 | 1.25 | 1.57 | 0.000 |
| 2 | 1.46 | 1.27 | 1.69 | 0.000 |
| ≥3 | 1.40 | 1.16 | 1.68 | 0.000 |
| Pre-existing Cardiovascular Diseases | ||||
| Hypertension (ref = No) | 0.96 | 0.87 | 1.05 | 0.356 |
| Cerebrovascular disease (ref = No) | 1.05 | 0.90 | 1.22 | 0.553 |
| Congestive heart failure (ref = No) | 0.99 | 0.76 | 1.28 | 0.911 |
| Myocardial infarction (ref = No) | 1.11 | 0.85 | 1.44 | 0.440 |
| Peripheral vascular disease (ref = No) | 0.90 | 0.78 | 1.03 | 0.134 |
| Renal disease (ref = No) | 0.89 | 0.75 | 1.06 | 0.206 |
| Moderate/severe liver disease (ref = No) | 1.32 | 0.98 | 1.77 | 0.064 |
| Primary Cancer Site 2 | ||||
| Lung (ref = No) | 1.00 | 0.90 | 1.11 | 0.972 |
| Melanoma (ref = No) | 0.48 | 0.43 | 0.55 | 0.000 |
| Renal cell carcinoma (ref = No) | 0.78 | 0.66 | 0.93 | 0.006 |
| urothelial (ref = No) | 1.25 | 1.05 | 1.49 | 0.013 |
| Head and neck (ref = No) | 1.08 | 0.92 | 1.27 | 0.358 |
| Meckel cell carcinoma (ref = No) | 0.56 | 0.32 | 1.00 | 0.052 |
| Liver (ref = No) | 1.28 | 1.05 | 1.56 | 0.013 |
| Time-Varying Covariate | ||||
| CAE × t | 1.16 | 1.00 | 1.34 | 0.047 |
ICI: immune checkpoint inhibitor; aHR: adjusted hazard ratio; 95% CI: 95% confidence interval. 1 Charlson Comorbidity Index (CCI) values were calculated based on diagnoses before or on the day of ICI initiation. The ICD 9 and 10 codes used to calculate the CCI were from Quan et al. (2005). 2 Primary cancer sites are based on diagnoses of primary cancers (excluding secondary diagnoses) before ICI initiation or 30 days after. Site variables are not mutually exclusive and patients may have multiple cancer sites.