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. 2022 Feb 25;14(5):1196. doi: 10.3390/cancers14051196

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Biglycan interacts with IGF-IR to regulate osteosarcoma cells behavior. Biglycan binds to IGF-IR and activates the signaling cascade of the receptor. This complex formation stimulates the IGF-IR uptake to the cytoplasm, its sumoylation, and deposition to the nucleus where the receptor, putatively, acts as a transcriptional regulator or target genes. This mechanism involves biglycan in prolonged IGF-IR activation. The synergistic action of these molecules increases MG63 osteosarcoma cells aggressiveness, leading to enhanced growth and chemoresistance.