Figure 3.

OGG1 (8-Oxoguanine glycosylase), MUTYH (mutY DNA glycosylase), APE1 (apurinic/apyrimidinic endodeoxyribonuclease-1) and PPARγ (peroxisome-proliferator-activated receptor gamma) gene expression modulation under H₂O₂ [10 mM], EGF, LY and PD treatments alone and combined in Nthy-ori 3-1 cells (a) vs. TPC-1 cells (b). Gene expression was analyzed by real-time qPCR. The histogram represented normalized data with GUSB gene in Nthy-ori 3-1, while the PPARγ expression data were normalized with β-Actin in TPC-1 cells. The expression of MUTYH was undetected in TPC-1 cells (five independent experiments). The results showed the average of three independent experiments. LY—LY294002; PD—PD98059; *—p < 0.05; **—p < 0.01; ***—p < 0.001 treated vs. quiescent cells; #—p < 0.05; ##—p < 0.01; ###—p < 0.001 cells with similar treatment.