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. 2022 Feb 28;11(5):831. doi: 10.3390/cells11050831

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of SOOME on angiogenesis of HUVECs. HUVECs co-cultured with SOOME at a cell ratio of 1:4 (osteocyte:HUVEC) on Matrigel in 24-well plate for 6 h until formed blood-vessel-like structures. Imaging (A) and quantification of node formation (B) in the co-culture of SOOME and HUVECs. (C) qPCR detected the expression of Angiopoietin-1 in the co-culture. The * symbol indicates p < 0.05 versus DMSO control; n = 3. Scale bar = 100 µm. Green = branches; orange = master segments; blue sky = meshes; red surrounded by blue = nodes; Ct, cycle number detected by qPCR machine for a relative amount of target genes.