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. 2022 Feb 27;14(5):1237. doi: 10.3390/cancers14051237

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Details of toxicities box plots showing the percentage of patients who presented specific toxicities. Panel (A) shows the frequency of immune-related adverse events (irAEs) stratified by target organs. Fever and asthenia were considered as target symptoms due to the frequency of these side effects. Panel (B) shows dermatological irAEs in detail. Abbreviations: EM, erythema multiforme; MCT, musculoskeletal and connective tissue; PPE, palmar-plantar erythrodysesthesia; NMSC, non-melanoma skin cancer; SSS, Stevens-Johnson syndrome; TEN, toxic epidermal necrolysis.