TABLE 1.
In vitro susceptibilities of 158 Senegalese isolates of P. falciparum to benflumetol, chloroquine, quinine, amodiaquine, pyronaridine, artemether, and pyrimethamine
| Drug | Chloroquine-susceptible isolates (n = 80)
|
Chloroquine-resistant isolates (n = 78)
|
P | ||
|---|---|---|---|---|---|
| IC50 (nM)a | 95% CI | IC50 (nM)a | 95% CI | ||
| Chloroquine | 35.7 | 30.2–40.9 | 245 | 221–269 | |
| Benflumetol | 63.4 | 53.1–73.7 | 47.9 | 38.4–57.9 | <0.025 |
| Quinine | 157 | 128–186 | 302 | 131–473 | <0.001 |
| Amodiaquine | 9.6 | 6.1–13.1 | 14.3 | 11.9–16.7 | <0.025 |
| Pyronaridine | 2.9 | 2.3–3.5 | 4.9 | 3.8–6.0 | <0.002 |
| Artemether | 5.3 | 4.1–6.5 | 5.2 | 3.6–6.8 | >0.45 |
| Pyrimethamine | 279 | 0–1,485 | 347 | 0–1,710 | <0.45 |
a
Values are the geometric mean IC50. The threshold IC50 for resistance to chloroquine is >100 nM.