Table 3.

Steroid-exposure timing prior to ICI initiation and its time-dependent association with ER hospitalization after ICI initiation.

Timing of Steroid Exposure Prior to ICI Initiation	0 to ≤3 Months Post ICI Initiation Hazard Ratios 1 (95% CI)	3 to ≤6 Months Post ICI Initiation Hazard Ratios 1 (95% CI)	≥6 Months Post ICI Initiation Hazard Ratios 1 (95% CI)
No steroids in 12 months before ICI	Ref	Ref	Ref
Steroids ≤1 month prior to ICI	1.62 (1.36–1.94) 2	1.37 (1.08–1.74) 2	1.01 (0.83–1.24)
Steroids 1 to ≤3 months prior to ICI	1.27 (1.01–1.58) 2	1.16 (0.88–1.54)	0.94 (0.75–1.17)
Steroids 3 to 12 months prior to ICI	1.15 (0.94–1.41)	1.11 (0.87–1.42)	0.84 (0.70–1.03)

¹ Hazard ratios estimated by time-dependent hazards model adjusted for sex, age, marital status, sequence of cancer diagnosis, year of diagnosis, and Charlson comorbidity index. ² p < 0.001.