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. 2022 Mar 1;14(5):1279. doi: 10.3390/cancers14051279

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Relative quantitative expression levels of CK20 and DEFA5 mRNA in blood and bone marrow of patients with esophageal carcinoma (EC) or non-malignant diseases and healthy controls (control cohort). Blood samples of 209 EC patients and 38 benign control patients, bone marrow samples of 147 EC patients, and 24 control patients with non-malignant diseases were semi-quantitatively analyzed for the expression of (A) CK20 and (B) DEFA5 mRNA. The determined cut-off values were calculated to be 4.64 relative mRNA expression units (EU) for CK20 in blood and 6.06 EU for CK20 in bone marrow. For DEFA5, the cut-off was 4.26 EU in blood and 599.3 EU in bone marrow. These values are shown as red lines in the graph.