Table 4.

Multivariate Cox regression analysis of independent factors and correlation with overall survival of esophageal carcinoma patients (all p-values in bold are regarded as statistically significant, BM: bone marrow, BL: blood, HR: hazard ratio, CI: confidence interval).

Variables	Overall Survival
	Univariate	Multivariate
	p-Value	HR (95% CI) p-Value
Without neoadjuvant therapy
CK20 detection in BM	0.006	2.28 (1.24–4.22) 0.008
DEFA5 detection in BL	0.047	0.74 (0.41–1.34) 0.318
UICC	<0.001	1.60 (1.19–2.17) 0.002
With neoadjuvant therapy
DEFA5 detection in BM	0.001	0.46 (0.26–0.80) 0.006
UICC	<0.001	1.53 (1.10–2.13) 0.012
DEFA5 detection in BM	0.001	0.46 (0.26–0.80) 0.006