Table 1.
Clinical characteristic of patients before NAC.
| Characteristics | All Patients | OPSII | MIBR | p-Value |
|---|---|---|---|---|
| 297 | 87 (29.3%) | 210 (70.7%) | ||
| Age (y) | 46.3 (44.8; 39.7–52) |
50.1 (48.5; 42.7–55.8) |
44.6 (43.5; 38.6–50.5) |
0.000 |
| Postmenopausal status - Yes - No |
100 (33.3%) 197 (65.7%) |
43 (49.4%) 44 (50.6%) |
57 (27.1%) 153 (72.9%) |
0.000 |
| BMI (Kg/m2) | 23.7 (23.4; 21.2–25.1) |
27.1 (26.6; 23.9–30.1) |
23.7 (23.4; 21.2–25.1) |
0.006 |
| BMI classes - BMI < 18 - BMI 18–24 - BMI 24–30 - BMI > 30 |
3 (1.3%) 155 (52.1%) 103 (34.6%) 36 (12%) |
0 (0%) 27 (29.9%) 38 (44.8%) 22 (25.3%) |
3 (1.4%) 128 (60.9%) 65 (31%) 14 (6.7%) |
0.000 |
| Breast related cancer antigens (BRCA) mutations | 53 (17.8%) | 4 (4.6%) | 49 (23.3%) | 0.000 |
| Histotype - Ductal invasive carcinoma - Lobular invasive carcinoma - Other |
198 (66.7%) 22 (7.4%) 77 (25.9%) |
61 (70.1%) 6 (6.9%) 20 (23%) |
137 (65.2%) 16 (7.6%) 57 (27.1%) |
0.715 |
| Tumor subtype - Luminal A - Luminal B - HER2+ - TN |
14 (4.7%) 133 (44.8%) 98 (33%) 52 (17.5%) |
8 (9.2%) 40 (46%) 24 (27.6%) 15 (17.2%) |
6 (2.9%) 93 (44.3%) 74 (35.2%) 37 (17.6%) |
0.095 |
| Grading - G1 - G2 - G3 |
4 (1.3%) 94 (31.7%) 199 (67%) |
3 (3.4%) 26 (29.9%) 58 (66.7%) |
1 (0.5%) 68 (32.4%) 141 (67.1%) |
0.125 |
| Tumor diameter (mm) | 41.6 (35; 27–50) |
44.2 (38; 27–56) |
40.5 (35; 26.7–50) |
0.038 |
| Clinical T - cT2 - cT3 - cT4 |
215 (72.4%) 64 (21.5%) 18 (6.1%) |
59 (67.8%) 20 (23%) 8 (9.2%) |
156 (74.3%) 44 (21%) 10 (4.8%) |
0.291 |
| Multifocality/multicentricity | 159 (53.5%) | 49 (56.3%) | 110 (52.4%) | 0.609 |
| Clinical N - cN0 - cN1 - cN2 - cN3 |
111 (37.4%) 131 (44.1%) 44 (14.8%) 11 (3.7%) |
29 (33.3%) 43 (49.4%) 14 (16.2%) 1 (1.1%) |
82 (39%) 88 (41.9%) 30 (14.3%) 10 (4.8%) |
0.304 |