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. 2022 Mar 2;11(5):865. doi: 10.3390/cells11050865

Figure 2.

Figure 2

Farnesylated lamins do not accumulate at nuclear ruptures but inhibiting farnesylation promotes rupture accumulation. Representative images of laser-induced nuclear rupture events in BJ-5ta cells stably expressing (A) GFP-LaA that underwent either control or ZmpSte24 siRNA knockdown, (B) GFP-LaA L647R, (C) FTI-treated GFP-LaA L647R, or (D) FTI-treated GFP-LaB1. All cells were imaged for at least 10 min after laser-induced nuclear rupture (purple arrowheads) to monitor for protein accumulation (yellow arrowheads). Scale bars, 10 μm.