Table 2.
MIPRIP analysis of the 12 identified prostate-specific TERT regulators.
| TERT Regulator | Regulators Used in At Least 20% of the Models | Number of Direct Regulators | Number of TERT Regulators |
|---|---|---|---|
| PITX1 | SMARCC1, TAF1 *, HEY1 *, POLR2A *, FOXO1, HNF4A, ESR1 *, RBBP5, SMAD1, SMARCB1 * | 10 | 5 |
| AR | MAFF, MAFK, ZBTB17, CREB3, GATA2, TCF4, CTCF *, EGR1 * | 8 | 2 |
| MITF | MXI1 *, ZNF263, SMC3, TAL1 *, MYC *, EP300, MAX * | 7 | 4 |
| CTCF | MAX *, PRDM16, YY1, RBBP5, REST *, POU2F2 *, FOXP2, EP300 | 8 | 3 |
| BHLHE40 | ARNTL, HIF1A *, SIN3AK20 *, EGR1 *, NCOR1, AR *, CEBPB, GABPA, ZNF143 | 9 | 4 |
| ETS1 | ETV2, PAX5 *, FOS, CEBPB, USF1, FOXA1, TCF7L2, IRF4, GATA2 | 9 | 1 |
| CEBPA | SP1, CLOCK, IKZF1 *, MYC *, NCOR1, FOXP2, JUN, SREBF1, MAZ * | 9 | 3 |
| E2F2 | E2F4 *, PML, E2F7, MAFK, ELF1, HEY1 *, EBF1, E2F6 *, MAFF, TCF12 * | 10 | 4 |
| NR2F2 | MXI1 *, TP53 *, USF1, E2F4 *, SF1, FOXP2, SIN3AK20 *, ZNF263 | 8 | 4 |
| IRF1 | NFKB.P50.P65 *, IRF2, SPI1, EGR1 *, MYB * | 5 | 3 |
| TFAP2C | TP63, MAX *, RAD21 *, RBPJ, SP1, POU5F1, ZFP36L1, MTA1, E2F1 *, EZH2, SETDB1 | 11 | 3 |
* TF binding to the TERT promoter (potential direct regulators of TERT).