Figure 1.

Schematic diagram of the chromosomal positions and domain structures of human SOX transcriptional factors. SOX family members are classified into eight subgroups based on the degree of sequence identity of the HMG motif, which is an evolutionarily conserved DNA-binding motif and is also a representative signature of the SOX family. Besides the shared HMG motif, different SOX members have their specific structure domains to achieve functional diversity. The chromosomal positions and domain structures of SOX members have been shown (Data referenced from Ref. [17] and website www.ncbi.nlm.nih.gov/gene/ (accessed on: 15 November 2021)). Abbreviations: SRY: Sex-determining region Y; SOX: Sex-determining region Y-related high-mobility group box; HMG: High-mobility group.