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View full-text article in PMC

. 2022 Feb 24;14(5):1165. doi: 10.3390/cancers14051165

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The roles and molecular mechanisms of SOX transcription factors in hepatocellular carcinoma (HCC). SOX members serve as master tumor drivers or suppressors to transcriptionally regulate key downstream targets or signaling pathways, therefore controlling the initiation and progression of HCC. Simultaneously, the dysregulated SOX expression is frequently observed in HCC, which is mainly attributed to promoter hypermethylation, signaling pathway regulation, and post-transcriptional modulation by miRNAs (microRNAs). This diagram was created by BioRender.com (accessed on: 28 November 2021). The red box represents tumor driver, and the blue box represents tumor suppressor. Abbreviations: SOX: Sex-determining region Y-related high-mobility group box; SRY: Sex-determining region Y; CSC: Cancer stem cell; 3′UTR: 3′ untranslated region; H3: Histone 3; EMT: Epithelial-mesenchymal transition.