TABLE 2.
Effects of OprM and OprD expression levels on susceptibilities of carbapenems and other antimicrobial agents
| Antibiotic | MICs (μg/ml) for strains with indicated phenotypea
|
|||||
|---|---|---|---|---|---|---|
| PAO1 OprM+ OprD+ | PAO1T OprM− OprD+ | PA1423 OprM++ OprD+ | PASE1 OprM+ OprD− | PA1425 OprM− OprD− | PA1426 OprM++ OprD− | |
| Imipenem | 1 | 1 | 1 | 16 | 16 | 16 |
| Meropenem | 0.5 | 0.125 | 4 | 4 | 0.5 | 16 |
| ER-35786 | 0.25 | 0.25 | 0.25 | 1 | 0.5 | 0.5 |
| Carbenicillin | 64 | 1 | 256 | 64 | 2 | 256 |
| Cefpirome | 2 | 0.25 | 4 | 2 | 0.25 | 8 |
| Sparfloxacin | 0.5 | 0.125 | 2 | 0.5 | 0.125 | 2 |
a
+, wild-type expression level; −, knockout mutation; ++, overexpression.