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. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of TRPV4 channel function at sites of inflammation (a) and the treated acupoint (b) of ankle AA rats. Establishing the inflammation pain and acupuncture intervention was referred to in the legend of Figure 5. Data show pain thresholds of injured plantars in response to mechanical (tactile allodynia) or heat (thermal hyperalgesia) stimulation. HC067047 (0.2 mM, 20 μL) (HC), a specific inhibitor of TRPV4, was administrated in the injured plantar 50 min before behavioral test (a), or in the treated ST36 20 min before 30-min needling. (b) Data represent means + SEM (n = 6–9), and are based on data from Zheng et al. (2021) [54].