Skip to main content
. 2022 Feb 25;11(5):809. doi: 10.3390/cells11050809

Figure 10.

Figure 10

Degranulation of human MCs induced by activation of TRPV1, TRPV2, TRPV4 and stretch-activated (SA) Cl− channels. Degranulation was determined as degree of degranulation induced by the TRPV1 activator capsaicin (1 µM) (data extracted from Gu et al. (2012) [48]), or as the contribution sensitive to specific inhibitors: 20 µM SKF96365 for TRPV2 to degranulation induced by hypotonic stress (230 compared with310 mOsm/L) (data extracted from (Wang and Schwarz (2012) [60]), or 500 nM HC067047 for TRPV4 to degranulation induced by compound 48/80 (data extracted from Mascarenhans et al. (2017) [61]), or 200 µM DIDS for the mechanical SA Cl− channel (see Section 3.1.2) (data extracted from Wang and Schwarz (2012) [60]). Data represent averages + SEM.