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. 2022 Feb 23;14(5):1139. doi: 10.3390/cancers14051139

Table 1.

Some evidence of the applications of liquid biopsy in oral cancer.

Study Country Type of Cancer Liquid Biopsy Technology Publication Type Reference
Lousada-Fernandez et al., 2018 Spain Oral cancer Liquid Biopsy Review [10]
Lin et al., 2018 Taiwan Oral Cancer Cell-Free DNA
Biomarker
Original Research [15]
Patel et al., 2016 India Oral Squamous Cell Carcinoma Circulating Tumor cells Original Research [19]
Economopoulou et al., 2017 Greece Head and Neck Squamous Cell Carcinoma Circulating Tumor Cells Review [20]
Oliveira-Costa et al., 2015 Brazil Oral Squamous Cell Carcinoma Circulating Tumor Cells Original Research [24]
Inhestern et al., 2015 Germany Oral and Oropharyngeal Squamous Cell Cancer Circulating Tumor Cells Original Research [25]
Li et al., 2016 China Oral Squamous Cell Carcinoma Exosomes Original Research [31]
Pang et al., 2021 China Oral Squamous Cell Carcinoma Exosomes Original Research [32]
Lu et al., 2021 China Oral Squamous Cell Carcinoma Exosomes Review [34]
Oh et al., 2020 South Korea Oral Cancer Salivary mRNA
Biomarker
Original Research [35]
Lu et al., 2015 Taiwan Oral Cancer Circulating miRNA
Biomarker
Original Research [36]
Liu et al., 2010 Taiwan Oral Cancer Circulating miRNA
Biomarker
Original Research [37]
Cristaldi et al., 2019 Italy Oral Squamous Cell Carcinoma Salivary Biomarker (ctDNA, EVs and miRNAs) Review [38]
Adeola et al., 2020 South Africa Oral Cancer Salivary Exosomes
Biomarker
Review [40]
Tsai et al., 2020 Taiwan Oral Squamous Cell Carcinoma Nuclear Magnetic Resonance Metabolomics Biomarker Original Research [43]
Ono et al., 2018 Japan Oral Cancer HSP-Enriched Properties of Extracellular Vesicles Original Research [45]
Fujiwara et al., 2018 Japan Oral Cancer Exosomes Original Research [48]
Spafford, et al., 2001 USA Head and Neck Squamous Cell Carcinoma Pretreatment Oral Rinse Microsatellite Analysis. Original Research [52]