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. 2022 Feb 23;11(5):776. doi: 10.3390/cells11050776

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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βIII-tubulin regulates mitochondrial volume. (A) Representative electron micrographs of NCI-H460 and A549 cells expressing control (H460 Ctrl_SH2, A549 Ctrl_SH27) and βIII-tubulin targeted shRNA (NCI-H460 βIII_SH4, A549 βIII_SH61). Mitochondria in the upper panels have been pseudocolored green to allow simple comparison of the two cell types (see Supplementary Figure S1C for uncolored original images). Scale bar 5 μm. (B) Mitochondrial circularity in A549 cells expressing control (A549 Ctrl_SH27) and βIII-tubulin targeted shRNA (A549 βIII_SH61) (mean ± SD of n = 2 independent experiments, p = 0.12). Points are the average of each independent experiment. (C) Mitochondrial volume in control and βIII-tubulin knockdown cells in A549 cells (Ci, mean ± SD of n = 3 independent experiments, p = 0.0033) and NCI-H460 cells (Cii, mean ± SD of n = 2 independent experiments, p = 0.0459). Points are the average of each independent experiment. * p < 0.05, ** p < 0.01.