Table 2.
PRR Gene Expression in O. tsutsugamushi-Infected C57BL/6 Mice
| Fold Change (D10 vs. D0) | ||||
|---|---|---|---|---|
| Gene/Alias (Encoded Protein) | Lung NanoString (Ref [49]) | Brain NanoString (Ref [49]) |
Brain RNAseq |
|
| CLR | Clec4e (Macrophage Inducible C-type Lectin; Mincle) | 36.00 | 441.21 | 14082.01 |
| Clec4d (Macrophage C-type Lectin; MCL) | - | - | 118.47 | |
| Clec5a (Myeloid DAP12-Associating Lectin 1; MDL) | 6.96 | 6.34 | 4.15 | |
| CLR Partner | Fcgr4 (Fcγ Receptor 4) | 18.77 | 517.89 | 138.43 |
| Fcgr1 (Fcγ Receptor 1) | 7.11 | 12.79 | 7.21 | |
| Fcgr3 (Fcγ Receptor 3) | 3.81 | 7.93 | 5.54 | |
| Fcgr2b (Fcγ Receptor 2b) | 3.20 | 14.81 | 5.37 | |
| TLR | Toll-like receptor 1 | 3.13 | 9.19 | 9.88 |
| Tlr2 | 1.97 | ns | 8.46 | |
| Tlr4 | 0.98 | 5.46 | 4.64 | |
| Tlr6 | 4.28 | - | 2.84 | |
| MyD88 | 1.85 | 3.54 | 2.86 | |
|
NLR and
RLR |
Nlrc5 (NLR Family CARD Domain Containing 5) | - | - | 79.53 |
| Nod1 (Nucleotide-Binding Oligomerization Domain-Containing Protein 1) | 1.38 | - | 4.35 | |
| Nod2 (Nucleotide-Binding Oligomerization Domain-Containing Protein 2) | 2.60 | ns | 4.48 | |
| Nlrp3 (NLR Family Pyrin Domain Containing 3) | 3.29 | - | 3.46 | |
| Ddx58 (RIG-I, retinoic acid-inducible gene I) | 0.80 | 6.53 | 4.61 | |
All values presented are statistically significant changes (p < 0.05) unless denoted not significant (ns).