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. 2022 Feb 24;11(5):787. doi: 10.3390/cells11050787

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Neutrophil-specific Dnmt3b deficiency does not affect the acute host response during Pseudomonas aeruginosa pneumonia. Neutrophil-specific Dnmt3b-deficient mice (Dnmt3b^fl/flMrp8^Cre) and littermate control (Dnmt3b^fl/fl) mice were infected with viable PAK (5 × 10⁶ CFU) via the airways and euthanized 6 or 24 h after infection. (A) Bacterial counts (colony forming units, CFU), (B) neutrophil numbers, (C) neutrophil CD11b expression, (D) myeloperoxidase (MPO), (E) elastase, (F) IL-β, IL-6, TNF levels, all in bronchoalveolar lavage fluid (BALF). Data are shown as bar graphs with mean + SEM, n = 8. * p < 0.05.