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. 2022 Mar 1;11(5):840. doi: 10.3390/cells11050840

Figure 4.

Figure 4

Functional regions of Tau protein. (A) Schematic representation of the equivalence between Tau amino acids translated from each exon and regional functions of Tau protein. (B) Differences on the length of different functional regions due to the inclusion or exclusion of exons 2, 3 and 10, indicated by vertical stripes. Tau 441 (4R2N) and Tau 352 (3R0N) are shown to highlight the differences. (C) Differences on the length of different functional regions of Tau due to the expansion of the protein with respect to Tau 441 (4R2N). Inclusion of exon 4a (pink, squared area) implies the extension of the N-terminal region, while inclusion of exon 6 (blue, horizontally stripped area) extends the molecule including a proline-rich exon that would extend the proline-rich region. (D) Differences on the length of Tau functional regions in isoforms lacking the C-terminal region. 6p and 6d isoforms lack the proline-rich region, the microtubule-binding region and the C-terminal end altogether, while W-Tau isoforms only lose the C-terminal end. Blue, diagonally stripped regions on isoforms 6p and 6d represent the translation of their respective specific sequences, which can have their own functions. Red stripped regions on the W-Tau isoform represent the unique 18 amino acid sequence characteristic of these isoforms, which may also have specific properties.