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DVL Binding and WNT Pathway Inhibition by Compounds 1, (S)-1, (R)-1 and 2.
|
|
|
| 1 | 2 | |
| EC50 ± SD (μM) a | EC50 ± SD (μM) b | |
| Compound | DVL1 Binding Inhibition | WNT Pathway Inhibition |
| 1 | 0.74 ± 0.08 | 3.46 ± 0.07 |
| (S)-1 | 0.49 ± 0.11 | 3.09 ± 0.05 |
| (R)-1 | 29.5 ± 0.9 | 19.49 ± 0.06 |
| 2 | 5.10 ± 0.09 | n.d. |
a Inhibition of DVL1 binding. b Inhibition of the WNT pathway.
