. Author manuscript; available in PMC: 2022 Mar 10.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1006–1017. doi: 10.1161/ATVBAHA.119.312141

Table.

Human Artery Tissue and Cellular eQTL Data Resources Available

Study	Tissue(s)	Sample size	Datasets	Platforms	Age (mean±SD)	Sex	Ancestry
Athero-Express Biobank Study⁷⁴	Atherosclerotic carotid artery plaque	1439	Histological plaque characteristics, SNP genotyping, DNA methylation, proteomics (plasma, urine, plaque)	Sirius Red, α-actin, CD34, CD68, and H&E staining, Affymetrix and Illumina SNP arrays (genotyping), Illumina 450K Methylation array, mass spectrometry and Luminex (proteomics)	68.8±9.3	67.9% male	100% European
STARNET⁵⁵	Atherosclerotic aortic root, nonatherosclerotic internal mammary artery, blood, subcutaneous adipose, abdominal adipose, liver, skeletal muscle	≈600	SNP genotyping, gene expression, cis/trans-eQTLs, networks	Human OmniExpressExome 8v1 array (genotyping), RNA-seq (~15–30M reads/sample)	65.8±8.7	70.3% male	100% European
STAGE⁷⁵	Atheroscelrotic aortic root, nonatherosclerotic arterial wall internal mammary artery, liver, skeletal muscle, pericardial mediastinal visceral fat, carotid artery lesions	109	Gene expression, cis-eQTLs	Affymetrix, GenomeWideSNP_6 array (genotyping), Affymetrix Human Genome U133 Plus 2.0 Array (gene expression)	66±8	90% male	100% European
BiKE⁷⁶	Atherosclerotic carotid artery plaque from endoarterectomy and nonatherosclerotic control artery, plasma	127 (plaque); 15 (control)	SNP genotyping, Gene expression, proteomics (plaque and plasma), cis-eQTLs, histology	Illumina Human 610 W- Quad Beadarrays (genotyping), Genotyping array, Affymetrix HT HU133A Plus array (gene expression), LC-MS/MS (proteomics)	70.0±8.9	80.2% male	100% European
ASAP⁷⁷	liver, mammary artery (medial and adventitial), and dilated and nondilated ascending aorta (medial and adventitial)	117	SNP genotyping, gene expression, plasma proteomics, cis-eQTLs	Illumina Human 610 W- Quad Beadarrays (genotyping), Affymetrix Human Exon 1.0 ST array (gene expression), LC-MS/MS (proteomics)	63.2±11.5	≈70.2% male	100% European
HAEC^78,79	HAECs from ascending aortic segment of transplant donors (control and Ox-PAPC treatment)	149	SNP genotyping, gene expression, coexpression network analysis, chromatin accessibility	Affymetrix Human SNP Array 6.0 (genotyping), Affymetrix HT HU133A array (gene expression), ATAC-seq	N/A	N/A	N/A
HCASMC^23,24	HCASMC from nondiseased donors	52	SNP genotyping, gene expression, cis-eQTL, sQTL, chromatin accessibility	Whole genome sequencing (30X), RNA-seq (≈50M reads/sample), ATAC-seq (≈45M reads/sample)	39.0±15.4	65.3% male	78% European, 10% Hispanic, 10% African, 2% Asian

ASAP indicates Advanced Study of Aortic Pathology; ATAC-Seq, assay for transposase-accessible chromatin-sequencing; BiKE, Biobank of Karolinska Carotid Endarterectomies; eQTL, expression quantitative trait locus; H&E, hematoxylin and eosin; HAEC, human aortic endothelial cell; HCASMC, Human coronary artery smooth muscle cells; LC-MS/MS, liquid chromatography with tandem mass spectrometry; N/A, not applicable; Ox-PAPC, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine; SNP, single nucleotide polymorphism; sQTL, splicing quantitative trait locus; STAGE, Stockholm Atherosclerosis Gene Expression; and STARNET, Stockholm-Tartu Atherosclerosis Reverse Network Engineering Task.