Appendix Table 5.
Multi-variables adjusted odds ratio of diabetes incident associated with Se stratums, sub-categorized by HDL-C levels
| HDL-C subgroups | Stratums | Incidence cases, n | Control, n | OR*(95% CI) Crude | OR† (95% CI) Model 1 | OR‡ (95% CI) Model 2 |
|---|---|---|---|---|---|---|
|
| ||||||
| Low (<1.04 mmol/L) | Q1 | 39 (24.68) | 32 (26.67) | 1.00 | 1.00 | 1.00 |
| Q2 | 38 (24.05) | 34 (28.33) | 0.92 (0.48–1.77) | 0.93 (0.45–1.93) | 0.77 (0.33–1.77) | |
| Q3 | 46 (29.11) | 22 (18.33) | 1.72 (0.86–3.42) | 2.34 (1.08–5.10) | 2.11 (0.97–5.08) | |
| Q4 | 35 (22.15) | 32 (26.67) | 0.88 (0.46–1.75) | 0.87 (0.42–1.83) | 0.69 (0.29–1.65) | |
| ρ for trend: 0.95 | ρ for trend: 0.86 | ρ for trend: 0.81 | ||||
|
| ||||||
| Medium (1.04~1.55 mmol/L) | Q1 | 66 (18.03) | 81 (23.08) | 1.00 | 1.00 | 1.00 |
| Q2 | 71 (19.40) | 77 (21.94) | 1.13 (0.72–1.79) | 1.35 (0.82–2.23) | 1.32 (0.75–2.33) | |
| Q3 | 107 (29.23) | 100 (28.49) | 1.31 (0.86–2.01) | 1.50 (0.95–2.38) | 1.41 (0.84–2.36) | |
| Q4 | 122 (33.33) | 93 (26.50) | 1.61 (1.06–2.46) | 1.67 (1.05–2.66) | 1.66 (1.05–2.76) | |
| ρ for trend: 0.10 | ρ for trend: 0.37 | ρ for trend: 0.39 | ||||
|
| ||||||
| High (≥1.55 mmol/L) | Q1 | 18 (18.37) | 42 (27.81) | 1.00 | 1.00 | 1.00 |
| Q2 | 17 (17.35) | 45 (29.80) | 0.88 (0.40–1.93) | 0.63 (0.25–1.59) | 0.71 (0.25–1.99) | |
| Q3 | 23 (23.47) | 33 (21.85) | 1.63 (0.76–3.50) | 1.42 (0.59–3.41) | 1.60 (0.53–4.86) | |
| Q4 | 40 (40.82) | 31 (20.53) | 3.01 (1.46–6.21) | 3.05 (1.27–7.32) | 3.17 (1.13–8.89) | |
| ρ for trend: <0.01 | ρ for trend: <0.01 | ρ for trend: <0.01 | ||||
Note: The interaction test between HDL-C categories and serum Se stratums: F=3.51, ρ<0.0001.
: Represent the crude odds ratios
: Odds ratios were adjusted by age at diagnosis (<30, 30–39, 40–49, 50–59, 60–69, ≥70), gender (male/female), BMIs (<18.5, 18.5–23.9, 24.0–27.9, ≥28.0), family history of diabetes (yes or no), physical exercise (no, occasionally, often), smoking index, (no smoking, 0–6.3, 6.4–14.0, 14.1–23.2, ≥23.3), lifetime total alcohol intake, (no drinking, 0–72.2, 72.3–167.5, 167.5–380.1, ≥380.1), triglyceride (<1.70 mmol/L, 1.70~2.25 mmol/L, >2.20 mmol/L), high-density lipoprotein (<1.04 mmol/L, 1.04–1.55 mmol/L, >1.55 mmol/L), and hypertension status (normal, elevated, stage I, stage II).
: Odds ratios in model 2 were further adjusted by serum level (μg/L) of Nickel, Cobalt, Copper, Zinc, Cadmium, Mercury, Chromium, Arsenic, and Magnesium (continues variables) on the basis of adjusted confounding factors in model 1.