Appendix Table 6.
Multi-variables adjusted odds ratio of diabetes incident associated with Se stratums, sub-categorized by LDL-C levels
| LDL-C subgroups | Stratums | Incidence cases, n | Control, n | OR*(95% CI) Crude | OR† (95% CI) Model 1 | OR‡ (95% CI) Model 2 |
|---|---|---|---|---|---|---|
|
| ||||||
| Low (<2.59 mmol/L) | Q1 | 68 (24.46) | 81 (30.00) | 1.00 | 1.00 | 1.00 |
| Q2 | 52 (18.71) | 56 (20.74) | 1.03 (0.53–1.99) | 1.08 (0.49–2.36) | 1.22 (0.65–2.29) | |
| Q3 | 80 (28.78) | 68 (25.19) | 1.33 (0.72–2.42) | 1.43 (0.70–2.94) | 1.57 (0.89–2.76) | |
| Q4 | 78 (28.06) | 65 (24.07) | 1.54 (0.85–2.78) | 1.46 (0.74–2.88) | 1.53 (0.84–2.79) | |
| ρ for trend: 0.25 | ρ for trend: 0.46 | ρ for trend: 0.50 | ||||
|
| ||||||
| Medium (2.59~3.34 mmol/L) | Q1 | 22 (14.38) | 37 (19.79) | 1.00 | 1.00 | 1.00 |
| Q2 | 32 (20.92) | 53 (28.34) | 1.02 (0.51–2.02) | 1.04 (0.49–2.22) | 0.89 (0.38–2.08) | |
| Q3 | 49 (32.03) | 56 (29.95) | 1.47 (0.77–2.83) | 1.74 (0.85–3.58) | 1.53 (0.67–3.49) | |
| Q4 | 50 (32.68) | 41 (21.93) | 2.05 (1.05–4.01) | 1.65 (0.77–3.50) | 1.75 (0.75–4.10) | |
| ρ for trend: 0.02 | ρ for trend: 0.19 | ρ for trend: 0.08 | ||||
|
| ||||||
| High (>=3.34 mmol/L) | Q1 | 33 (17.28) | 37 (22.42) | 1.00 | 1.00 | 1.00 |
| Q2 | 42 (21.99) | 47 (28.48) | 1.00 (0.54–1.88) | 1.11 (0.55–2.25) | 1.18 (0.51–2.72) | |
| Q3 | 47 (24.61) | 31 (18.79) | 1.70 (0.89–3.27) | 1.85 (0.89–3.84) | 1.87 (0.77–4.53) | |
| Q4 | 69 (36.13) | 50 (30.30) | 1.55 (0.85–2.80) | 1.90 (0.96–3.76) | 1.83 (0.81–4.12) | |
| ρ for trend: 0.12 | ρ for trend: 0.09 | ρ for trend: 0.24 | ||||
Note: The interaction test between LDL-C categories and serum Se stratums: F=1.85, ρ=0.042.
: Represent the crude odds ratios
: Odds ratios were adjusted by age at diagnosis (<30, 30–39, 40–49, 50–59, 60–69, ≥70), gender (male/female), BMIs (<18.5, 18.5–23.9, 24.0–27.9, ≥28.0), family history of diabetes (yes or no), physical exercise (no, occasionally, often), smoking index, (no smoking, 0–6.3, 6.4–14.0, 14.1–23.2, ≥23.3), lifetime total alcohol intake, (no drinking, 0–72.2, 72.3–167.5, 167.5–380.1, ≥380.1), triglyceride (<1.80 mmol/L, 1.80~2.20 mmol/L, ≥2.20 mmol/L), high-density lipoprotein (<1.04 mmol/L, 1.04–1.55 mmol/L, ≥1.55 mmol/L), and hypertension status (normal, elevated, stage I, stage II).
: Odds ratios in model 2 were further adjusted by serum level (μg/L) of Nickel, Cobalt, Copper, Zinc, Cadmium, Mercury, Chromium, Arsenic, and Magnesium (continues variables) on the basis of adjusted confounding factors in model 1.