Table 3.
Multi-variables adjusted odds ratio of diabetes incident associated with Se stratums, sub-categorized by gender
| Gender subgroups | Stratums | Incidence cases, n | Control, n | OR*(95% CI) Crude | OR† (95% CI) Model 1 | OR‡ (95% CI) Model 2 | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| Male | Q1 | 83 (18.20) | 104 (22.66) | 1.00 | 1.00 | 1.00 | |
| Q2 | 87 (19.08) | 111 (24.18) | 1.00 (0.67–1.51) | 1.24 (0.77–1.99) | 1.33 (0.76–2.33) | ||
| Q3 | 129 (28.29) | 120 (26.14) | 1.35 (0.91–1.99) | 1.58 (1.00–2.49) | 1.65 (1.02–2.84) | ||
| Q4 | 157 (34.43) | 124 (27.02) | 1.69 (1.13–2.52) | 1.85 (1.15–2.97) | 1.74 (1.09–3.06) | ||
| ρ for trend: 0.01 | ρ for trend: 0.08 | ρ for trend: 0.31 | |||||
|
|
|||||||
| Female | Q1 | 40 (24.10) | 51 (31.29) | 1.00 | 1.00 | 1.00 | |
| Q2 | 39 (23.49) | 45 (27.61) | 1.11 (0.61–2.01) | 1.12 (0.55–2.28) | 0.98 (0.41–2.36) | ||
| Q3 | 47 (28.31) | 35 (21.47) | 1.62 (0.90–2.92) | 1.93 (0.94–3.94) | 1.76 (0.76–4.09) | ||
| Q4 | 40 (24.10) | 32 (19.63) | 1.55 (0.79–3.06) | 1.69 (0.79–3.77) | 1.33 (0.42–4.19) | ||
| ρ for trend: 0.32 | ρ for trend: 0.32 | ρ for trend:0.59 | |||||
|
|
|||||||
| Total | Q1 | 123 (19.77) | 155 (24.92) | 1.00 | 1.00 | 1.00 | |
| Q2 | 126 (20.26) | 156 (25.08) | 1.05 (0.75–1.47) | 1.26 (0.86–1.85) | 1.29 (0.82–2.03) | ||
| Q3 | 176 (28.30) | 155 (24.92) | 1.42 (1.03–1.96) | 1.62 (1.17–2.35) | 1.62 (1.05–2.51) | ||
| Q4 | 197 (31.67) | 156 (25.08) | 1.70 (1.21–2.38) | 1.79 (1.21–2.64) | 1.64 (1.02–2.65) | ||
| ρ for trend: <0.01 | ρ for trend: 0.12 | ρ for trend:0.20 | |||||
Note: The interaction test between gender and serum Se stratums: F=1.97, ρ=0.06.
: Represent the crude odds ratios
: Odds ratios were adjusted by age at diagnosis (<30, 30–39, 40–49, 50–59, 60–69, ≥70), BMIs (<18.5, 18.5–23.9, 24.0–27.9, ≥28.0), family history of diabetes (yes or no), physical exercise (no, occasionally, often), smoking index, (no smoking, 0–6.3, 6.4–14.0, 14.1–23.2, ≥23.3), lifetime total alcohol intake, (no drinking, 0–72.2, 72.3–167.5, 167.5–380.1, ≥380.1), triglyceride (<1.80 mmol/L, 1.80~2.20 mmol/L, ≥2.20 mmol/L), HDL-C(<1.04 mmol/L, 1.04–1.55 mmol/L, ≥1.55 mmol/L), LDL-C (<3.37 mmol/L, 3.37–4.11 mmol/L, ≥4.12 mmol/L), and hypertension status (normal, elevated, stage I, stage II).
: Odds ratios in model 2 were further adjusted by serum level (μg/L) of Nickel, Cobalt, Copper, Zinc, Cadmium, Mercury, Chromium, Arsenic, and Magnesium (continues variables) on the basis of adjusted confounding factors in model 1.