Table 4.
Multi-variables adjusted odds ratio of diabetes incident associated with Se stratums, sub-categorized by age
| Age subgroups | Stratums | Incidence cases, n | Control, n | OR*(95% CI) Crude | OR† (95% CI) Model 1 | OR‡ (95% CI) Model 2 | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| <45 | Q1 | 23 (18.40) | 31 (22.79) | 1.00 | 1.00 | 1.00 | |
| Q2 | 27 (21.60) | 45 (33.09) | 0.85 (0.39–1.85) | 0.98 (0.33–2.92) | 0.68 (0.28–1.40) | ||
| Q3 | 41 (32.80) | 33 (24.26) | 1.77 (0.86–4.13) | 2.33 (0.63–6.56) | 1.39 (0.53–3.63) | ||
| Q4 | 34 (27.20) | 27 (19.85) | 2.35 (0.94–5.90) | 2.45 (0.70–6.55) | 1.13 (0.32–2.75) | ||
| ρ for trend: 0.02 | ρ for trend: 0.11 | ρ for trend:0.27 | |||||
|
|
|||||||
| 45–64 | Q1 | 74 (19.63) | 80 (21.98) | 1.00 | 1.00 | 1.00 | |
| Q2 | 77 (20.42) | 90 (24.73) | 0.80 (0.50–1.28) | 1.09 (0.68–1.75) | 0.90 (0.53–1.54) | ||
| Q3 | 97 (25.73) | 98 (26.92) | 1.00 (0.65–1.54) | 1.30 (0.82–2.05) | 1.12 (0.66–1.90) | ||
| Q4 | 129 (34.22) | 96 (26.37) | 1.49 (0.94–2.37) | 1.74 (1.10–2.75) | 1.49 (1.01–2.12) | ||
| ρ for trend: 0.01 | ρ for trend: 0.04 | ρ for trend:0.15 | |||||
|
|
|||||||
| >=65 | Q1 | 26 (21.67) | 44 (36.07) | 1.00 | 1.00 | 1.00 | |
| Q2 | 22 (18.33) | 21 (17.21) | 2.01 (0.91–4.44) | 2.17 (0.76–6.20) | 1.71 (0.59–4.92) | ||
| Q3 | 38 (31.67) | 24 (19.67) | 3.26 (1.44–7.36) | 4.60 (1.50–8.02) | 2.91 (1.06–7.97) | ||
| Q4 | 34 (28.33) | 33 (27.05) | 1.84 (0.89–3.80) | 1.55 (0.60–4.00) | 1.36 (0.95–3.68) | ||
| ρ for trend: 0.83 | ρ for trend: 0.50 | ρ for trend:0.68 | |||||
Note: The interaction test between age-group and serum Se stratums: F=1.91, ρ=0.035.
: Represent the crude odds ratios
: Odds ratios were adjusted by gender (male/female), BMIs (<18.5, 18.5–23.9, 24.0–27.9, ≥28.0), family history of diabetes (yes or no), physical exercise (no, occasionally, often), smoking index, (no smoking, 0–6.3, 6.4–14.0, 14.1–23.2, ≥23.3), lifetime total alcohol intake, (no drinking, 0–72.2, 72.3–167.5, 167.5–380.1, ≥380.1), triglyceride (<1.70 mmol/L, 1.70~2.25 mmol/L, >2.20 mmol/L), high-density lipoprotein (<1.04 mmol/L, 1.04–1.55 mmol/L, >1.55 mmol/L), low-density lipoprotein (<2.60 mmol/L, 2.60–4.11 mmol/L, >4.12 mmol/L), and hypertension status (normal, elevated, stage I, stage II).
: Odds ratios in model 2 were further adjusted by serum level (μg/L) of Nickel, Cobalt, Copper, Zinc, Cadmium, Mercury, Chromium, Arsenic, and Magnesium (continues variables) on the basis of adjusted confounding factors in model 1.