Table 5.
Multi-variables adjusted odds ratio of diabetes incident associated with Se stratums, sub-categorized by BMI categories
| BMI subgroups | Stratums | Incidence cases, n | Control, n | OR*(95% CI) Crude | OR† (95% CI) Model 1 | OR‡ (95% CI) Model 2 | |
|---|---|---|---|---|---|---|---|
|
| |||||||
| <24.0 | Q1 | 32 (16.49) | 82 (24.70) | 1.00 | 1.00 | 1.00 | |
| Q2 | 26 (13.40) | 98 (29.52) | 0.68 (0.38–1.23) | 0.63 (0.34–1.19) | 0.61 (0.30–1.22) | ||
| Q3 | 66 (34.02) | 75 (22.59) | 2.26 (1.33–3.81) | 3.07 (1.24–5.81) | 2.06 (1.07–3.97) | ||
| Q4 | 70 (36.08) | 77 (23.19) | 3.33 (2.18–3.92) | 4.25 (1.28–7.94) | 2.21 (1.12–4.03) | ||
| ρ for trend: <0.01 | ρ for trend: <0.01 | ρ for trend: <0.01 | |||||
|
|
|||||||
| 24.0–27.9 | Q1 | 54 (19.01) | 57 (24.78) | 1.00 | 1.00 | 1.00 | |
| Q2 | 66 (23.24) | 45 (19.57) | 2.20 (0.97–5.48) | 2.50 (0.79–4.86) | 1.46 (0.78–2.73) | ||
| Q3 | 74 (26.06) | 65 (28.26) | 1.11 (0.47–2.63) | 1.63 (0.49–5.45) | 1.21 (0.67–2.19) | ||
| Q4 | 90 (31.69) | 63 (27.39) | 2.37 (1.12–6.11) | 3.74 (1.09–6.85) | 2.39 (1.15–4.05) | ||
| ρ for trend: 0.87 | ρ for trend: 0.50 | ρ for trend: <0.01 | |||||
|
|
|||||||
| >=28 | Q1 | 37 (25.69) | 16 (26.67) | 1.00 | 1.00 | 1.00 | |
| Q2 | 34 (23.61) | 13 (21.67) | 1.59 (0.20–2.69) | 1.06 (0.40–2.78) | 1.00 (0.34–2.93) | ||
| Q3 | 36 (25.00) | 15 (25.00) | 1.79 (0.45–2.41) | 1.37 (0.54–3.51) | 1.14 (0.39–3.07) | ||
| Q4 | 37 (25.69) | 16 (26.67) | 1.79 (0.44–2.29) | 1.02 (0.41–2.57) | 0.86 (0.30–2.53) | ||
| ρ for trend: 0.78 | ρ for trend: 0.94 | ρ for trend: 0.84 | |||||
Note: The interaction test between BMI group and serum Se stratums: F=9.01, ρ<0.0001.
: Represent the crude odds ratios
: Odds ratios were adjusted by age at diagnosis (<30, 30–39, 40–49, 50–59, 60–69, ≥70), gender (male/female), family history of diabetes (yes or no), physical exercise (no, occasionally, often), smoking index, (no smoking, 0–6.3, 6.4–14.0, 14.1–23.2, ≥23.3), lifetime total alcohol intake, (no drinking, 0–72.2, 72.3–167.5, 167.5–380.1, ≥380.1), triglyceride (<1.70 mmol/L, 1.70~2.25 mmol/L, >2.20 mmol/L), high-density lipoprotein (<1.04 mmol/L, 1.04–1.55 mmol/L, >1.55 mmol/L), low-density lipoprotein (<2.60 mmol/L, 2.60–4.11 mmol/L, >4.12 mmol/L), and hypertension status (normal, elevated, stage I, stage II).
: Odds ratios in model 2 were further adjusted by serum level (μg/L) of Nickel, Cobalt, Copper, Zinc, Cadmium, Mercury, Chromium, Arsenic, and Magnesium (continues variables) on the basis of adjusted confounding factors in model 1.