Appendix Table 3.
Multi-variables adjusted odds ratio of diabetes incident associated with Se stratums, sub-categorized by hypertension status
| Hypertension subgroups | Stratums | Incidence cases, n | Control, n | OR*(95% CI) Crude | OR† (95% CI) Model 1 | OR‡ (95% CI) Model 2 |
|---|---|---|---|---|---|---|
|
| ||||||
| Normal (<120/80 mmHg) | Q1 | 35 (19.77) | 43 (24.71) | 1.00 | 1.00 | 1.00 |
| Q2 | 33 (18.64) | 50 (28.74) | 1.01 (0.43–2.23) | 0.77 (0.40–1.50) | 1.09 (0.53–2.26) | |
| Q3 | 55 (31.07) | 43 (24.71) | 1.97 (0.86–3.25) | 1.70 (0.89–3.25) | 1.24 (0.58–2.64) | |
| Q4 | 54 (30.51) | 38 (24.84) | 2.21 (1.21–3.52) | 1.85 (0.94–3.66) | 1.31 (0.68–2.90) | |
| ρ for trend: 0.01 | ρ for trend: 0.01 | ρ for trend: 0.63 | ||||
|
| ||||||
| Elevated (120–129/80 mmHg) | Q1 | 32 (16.93) | 30 (21.58) | 1.00 | 1.00 | 1.00 |
| Q2 | 38 (20.11) | 28 (20.14) | 1.98 (0.47–4.34) | 1.46 (0.67–3.20) | 0.67 (0.32–1.43) | |
| Q3 | 63 (33.33) | 39 (28.06) | 1.46 (0.47–4.51) | 1.74 (0.84–3.62) | 1.48 (0.72–3.04) | |
| Q4 | 56 (29.63) | 42 (30.22) | 1.83 (0.49–5.84) | 1.30 (0.63–2.66) | 1.93 (1.00–4.06) | |
| ρ for trend: 0.92 | ρ for trend: 0.73 | ρ for trend: 0.01 | ||||
|
| ||||||
| Hypertension (≥130/80 mmHg) | Q1 | 56 (21.88) | 82 (26.54) | 1.00 | 1.00 | 1.00 |
| Q2 | 55 (21.48) | 78 (25.24) | 1.03 (0.64–1.68) | 1.26 (0.74–2.14) | 1.21 (0.61–2.38) | |
| Q3 | 58 (22.66) | 73 (23.62) | 1.16 (0.72–1.89) | 1.34 (0.79–2.28) | 1.27 (0.71–2.39) | |
| Q4 | 87 (33.98) | 76 (24.60) | 1.68 (1.06–2.65) | 1.74 (1.08–2.90) | 1.63 (1.05–2.72) | |
| ρ for trend: 0.04 | ρ for trend: 0.21 | ρ for trend: 0.42 | ||||
Note: The interaction test between hypertension status and serum Se stratums: F=2.62, ρ=0.003.
: Represent the crude odds ratios
: Odds ratios were adjusted by age at diagnosis (<30, 30–39, 40–49, 50–59, 60–69, ≥70), gender (male/female), BMIs (<18.5, 18.5–23.9, 24.0–27.9, ≥28.0), family history of diabetes (yes or no), physical exercise (no, occasionally, often), smoking index, (no smoking, 0–6.3, 6.4–14.0, 14.1–23.2, ≥23.3), lifetime total alcohol intake, (no drinking, 0–72.2, 72.3–167.5, 167.5–380.1, ≥380.1), triglyceride (<1.70 mmol/L, 1.70~2.25 mmol/L, >2.20 mmol/L), high-density lipoprotein (<1.04 mmol/L, 1.04–1.55 mmol/L, >1.55 mmol/L), low-density lipoprotein (<2.60 mmol/L, 2.60–4.11 mmol/L, >4.12 mmol/L).
: Odds ratios in model 2 were further adjusted by serum level (μg/L) of Nickel, Cobalt, Copper, Zinc, Cadmium, Mercury, Chromium, Arsenic, and Magnesium (continues variables) on the basis of adjusted confounding factors in model 1.