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. Author manuscript; available in PMC: 2022 Mar 10.
Published in final edited form as: Nat Metab. 2021 Oct 25;3(11):1552–1568. doi: 10.1038/s42255-021-00481-w

Extended Data Fig. 5 |. Changes in body weight and insulin sensitivity mediated by adipose Ndufv2 overexpression.

Extended Data Fig. 5 |

Related to Fig. 6. Eight-week old females or males of (a – b) C57BL/6 J or (c – j) A/J mice were injected with AAV vectors expressing either GFP or NDUFV2 in an adipose-specific manner and fed a HF/HS diet for eight additional weeks. Changes in (A - D) fat mass and total body weight measured every two-weeks (females n = 7 per group; males n = 8 per group), (E and H) ITT, (F and I) end-point HOMA-IR and (G and J) fasting insulin levels (F – A/J n = 8 per group; M – A/J GFP n = 7, NDUFV2 n = 8) are shown. Data are presented as mean ± SEM. P values were calculated using (A – E and H) Repeated measures 2-factor ANOVA corrected by post-hoc ‘Holm-Sidak’s’ multiple comparisons test; (F, G, I and J) Unpaired two-tailed Student’s t test.