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. 2022 Feb 23;23(5):2468. doi: 10.3390/ijms23052468

Figure 5.

Figure 5

In vivo imaging of anti-EGFR dye conjugates. A431-xenografted mice were intravenously injected into the tail vein with a single dose of 150 µL Alexa Fluor 647-labeled DM-AF647 (15 µM in PBS), DD1-AF647 (15 µM in PBS), DFc-AF647 (15 µM in PBS), or scFvFc-AF647 (10 µM in PBS) (n = 2 mice per group). Whole-body imaging was performed at indicated time points post-injection using the Lago imager (Spectral Instruments Imaging, Tucson, AZ, USA). The tumor is located at the lower right flank (red circle) as indicated for the PBS treated control mouse.