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Changes in gene expression in APP/BIN1/COPS5 3xTg-AD mice. PSEN1, PSEN2, and APOE mRNA levels were analyzed in wild-type (n = 4) and APP/BIN1/COPS5 3xTg-AD (n = 4) mice. Data are expressed as mean ± S.E.M. and as fold-changes compared to mRNA levels in wild-type mice; * p < 0.05. APOE, apolipoprotein E, PSEN, presenilin.
