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Sirtuins are regulated in APP/BIN1/COPS5 3xTg-AD mice. (A) Sirtuin activity was measured as indicated under Materials and Methods. (B) SIRT1 mRNA levels were measured by qPCR in samples from both wild-type (n = 4) and APP/BIN1/COPS5 3xTg-AD (n = 4) mice. Data are expressed as mean ± S.E.M; * p < 0.05. OD, optical density, SIRT, sirtuin.
