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HDACs are regulated in APP/BIN1/COPS5 3xTg-AD mice. (A) HDAC activity was measured as indicated under Materials and Methods. (B) HDAC3 mRNA levels were measured by qPCR in samples from wild-type (n = 4) and APP/BIN1/COPS5 3xTg-AD (n = 4) mice. Data are expressed as mean ± S.E.M; * p < 0.05.
