Figure 1.

Analysis for the complete data set (a) Principal component analysis to complete data for (left) endometabolome, the color patterns correspond to DMEM (blue), palmitic acid + tibolone (magenta), tibolone (light green), control (red), palmitic acid (purple). The exometabolome (right) represent palmitic acid (orange), control (dark green), DMEM (light blue), tibolone (pink) and palmitic acid + tibolone (yellow). (b) Partial least squares discriminant analysis for (left) endometabolome and (right) exometabolome. The color patterns are the same as PLS-DA. (c,d) Specific analysis for the endometabolome (c) Principal component analysis and (d) partial least squares discriminant analysis, where treatments are represented with tibolone (pink), control (red), DMEM (light green), palmitic acid (light blue), palmitic acid + tibolone (dark blue). (e,f) Specific analysis for the exometabolome. The pattern colors are the same as the endometabolome analysis.