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. 2022 Mar 3;19(5):2972. doi: 10.3390/ijerph19052972

Table 5.

Summary of reaction conditions for the synthesis of naringin esters by lipase.

Acyl Donor Enzyme Enzyme Conc., Molar Ratio Solvent Reaction Conversion Ref.
(Naringin: Acyl Donor)
Vinyl acetate Whole-cell catalyst Whole-cell 50 mg/mL, 1:50 Organic solvent 50 °C, 96 h 41.03%, [10]
Vinyl octanoate Aspergillus oryzae 91.40%
Vinyl butyrate Novozym 435 Enzyme 80 g/L, 1:10 Acetone 60 °C, 144 h 90% [12]
Oleic acid Lipozyme TL IM Enzyme 10 g/L, 1:20 Acetonitrile 40 °C, 48 h 93.10% [14]
40 °C, 24 h 92.17%
Coconut oil Novozym 435 Enzyme 5 g/L, 1:6 Acetonitrile 65 °C, 90 h 75.43%, [25]
Linseed oil 76.70%,
Sunflower oil 85.08%
Ricinoleic acid Novozym 435 Enzyme 20 g/L, 1:3 Acetone 50 °C, 120 h 33% [26]
Oleic acid Novozym 435 Enzyme 15 g/L, 1:4 Acetone: tert-amyl alcohol (2:1) 50 °C, 96 h 78.4%, [27]
Linoleic acid 77.6%,
Linolenic acid 86.6%
Lauric acid Novozym 435 Enzyme 12 g/L, 1:5 Acetone 45 °C, 96 h 80–90% [28]
Oleic acid
Linolenic acid
Vinyl laurate Novozym 435 Enzyme 17 g/L, 1:10 Acetonitrile 50 °C, 8 h 50% [29]
Acetic anhydride Lipozyme TL IM Enzyme 3 g/L, 1:5 Acetonitrile 40 °C, 8 h 98.51% This study
Vinyl acetate Lipozyme TL IM Enzyme 3 g/L, 1:5 Acetonitrile 40 °C, 24 h 97.54% This study