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. 2022 Feb 24;23(5):2510. doi: 10.3390/ijms23052510

Figure 2.

Figure 2

Effects of LiCl/pilocarpine SE, the effect of adenosine kinase inhibitor 5-ITU on the total duration of hippocampal ADs (mean + SEM), and the threshold intensity for elicitation of hippocampal afterdischarge (mean + SEM) in seven age groups. From left to right: (A) duration of hippocampal ADs, (B) threshold intensity. Black color—control rats, red color—control animals given 3.1 mg/kg of 5-ITU, blue color—LiCl/pilocarpine SE rats, green color—LiCl/pilocarpine SE rats given 3.1 mg/kg of 5-ITU (see inset). From top to bottom: 12-, 15-, 18-, 25-, 32-, and 45-day-old rats. (A) Abscissae: number of stimulations; ordinates: the total duration of ADs in seconds. One or three asterisks denote significant differences from corresponding control ADs for * p < 0.05 or *** p < 0.001, respectively. Circles denote significant differences from corresponding ADs in 5-ITU-pretreated rats compared to age-matched controls or SE rats for * p < 0.05. Hashtags denote significant changes from between 5-ITU-pretreated SE rats compared to age-matched controls for * p < 0.05. (B) Ordinates: intensity of stimulation in mA. One or three asterisks denote a significant difference from corresponding control ADs for * p < 0.05 or *** p < 0.001, respectively. Circles denote significant differences from corresponding thresholds in 5-ITU-pretreated rats compared to age-matched SE rats for * p < 0.05.