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. 2022 Feb 25;23(5):2554. doi: 10.3390/ijms23052554

Figure 1.

Figure 1

MPO inhibition did not reduce mycobacterial numbers or inflammatory infiltrates in infected mice. C3HeB/FeJ mice were aerosol-infected with 100–150 CFUs H37Rv, and bacterial burdens were calculated by CFU analysis at 25 dpi (pre-treatment) or 35 dpi (Captisol® (San Diego, CA, USA), ABAH) for lungs, spleens, and livers (A). Depicted are data from two independent experiments pooled in one graph. Error bars indicate SEM, ordinary one-way ANOVA with Tukey’s multiple comparisons test. Ziehl–Neelsen stainings counterstained with Hemalaun showed no differences in inflammatory infiltrates and mycobacterial distribution (arrowheads) within lungs of M. tuberculosis infected mock- vs. ABAH-treated C3HeB/FeJ mice (B). Lungs were removed at day 35, embedded in paraffin, and stained. Depicted are representative pictures.