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. 2022 Feb 23;23(5):2444. doi: 10.3390/ijms23052444

Table 1.

Summary of data from mast cell depletion papers.

Study Wound Type Targeting
Method		 Key Results
Egozi (2003)
[26]		 Excisional Genetic
(KitW/W-v)		 No change:
  • -

    Reepithelialization (microscopic)

  • -

    Vascularity (CD-31)

  • -

    Collagen (hydroxyproline)

  • -

    Macrophages (MOMA-2)

  • -

    T cells (CD-3)

Decrease:
  • -

    Neutrophils (GR-1)
Iba (2004)
[30]		 Excisional Genetic
(KitW/W-v)		 No change:
  • -

    Wound closure (macroscopic)

Increase:
  • -

    Collagen (hydroxyproline)
Weller (2006)
[27]		 Excisional Genetic
(KitW/W-v)		 Decrease:
  • -

    Wound closure (macroscopic)

  • -

    Neutrophils (MPO activity)

  • -

    Vascular permeability (Evans blue)
Shiota (2010)
[34]		 Thermal
(2nd degree scald)		 Genetic
(KitW/W-v)		 No change:
  • -

    Wound closure (macroscopic)

  • -

    Reepithelialization (microscopic)

Decrease:
  • -

    Dermal thickness (microscopic)

  • -

    Wound edge fibrosis (trichrome)
Younan (2010)
[41]		 Thermal
(2nd degree scald)		 Genetic
(KitW/W-v)		 Decrease:
  • -

    Erythema (macroscopic)

  • -

    Ulceration (macroscopic)

Increase:
  • -

    Hair re-growth (macroscopic)
Younan (2011)
[36]		 Excisional
+/micro-deformation		 Genetic
(KitW/W-v)		 No change:
  • -

    Collagen (trichrome)

Decrease:
  • -

    Granulation tissue

  • -

    Cell proliferation (Ki-67)

  • -

    Vascularity (CD-31)

  • -

    Collagen maturation (Herovici)
Wulff (2012)
[35]		 Incisional
(fetal skin)		 Genetic
(KitW/W-v)		 Decrease:
  • -

    Scar size (microscopic)
Antsiferova (2013)
[28]		 Excisional Genetic
(Cre-Master - Cpa3Cre/+)		 No change:
  • -

    Wound area (macroscopic)

  • -

    Reepithelialization (microscopic)

  • -

    Granulation tissue

  • -

    Neutrophils (MPO activity)
Nauta (2013)
[31]		 Splinted
excisional		 Genetic
(KitW-sh/W-sh;
KitW/W-v;
Cpa3-Cre;Mcl-1fl/fl)		 No change:
  • -

    Wound size (macroscopic)

  • -

    Scar area (microscopic)

  • -

    Collagen density (trichrome)
Willenborg (2014)
[29]		 Excisional Genetic
(Mcpt5-Cre/iDTR)		 No change:
  • -

    Wound size (macroscopic)

  • -

    Reepithelialization (microscopic)

  • -

    Granulation tissue

  • -

    Myofibroblasts (α-SMA)

  • -

    Collagen organization (picrosirius red)

  • -

    Neutrophils (Ly-6G/CD-11b)

  • -

    Macrophages (F4/80/CD-11b)

Decrease:
  • -

    Early panniculus carnosus

  • -

    contraction (microscopic)
Tellechea (2016)
[32]		 Diabetic
excisional		 Genetic
(KitW/W-v;
KitW-sh/W-sh)		 Increase:
  • -

    Wound size (macroscopic)

Decrease:
  • -

    Reepithelialization (microscopic) †
Nishida (2019) [42] Excisional Genetic
(KitW-sh/W-sh;
Mas-TRECK)		 Increase:
  • -

    Wound size (macroscopic)
Zimmermann (2019)
[33]		 Infected
excisional		 Genetic
(KitW/W-v;
Cpa-Cre;Mcl-1fl/fl)		 Increase:
  • -

    Bacterial burden

  • -

    Wound size (macroscopic) *

† shown for KitW/W-v mice only. * no change in uninfected wounds.