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. 2022 Feb 23;23(5):2444. doi: 10.3390/ijms23052444

Table 2.

Summary of data from neutrophil depletion papers.

Study Wound Type Targeting
Method		 Key Results
Simpson (1972) [43] Incisional Antibody
(anti-neutrophil serum)		 No change:
  • -

    Monocytes

  • -

    Cellularity

  • -

    Repair

  • -

    Connective tissue
Dovi (2003) [44] Excisional Antibody
(anti-GR-1)		 No change:
  • -

    Collagen (hydroxyproline)

  • -

    Macrophages (MOMA-2)

Increase:
  • -

    Reepithelialization (microscopic) †
Grguric-Smith [46] Infected
excisional		 Antibody
(anti-Ly-6G)		 Decrease:
  • -

    Wound closure (macroscopic)

Increase:
  • -

    Bacterial burden

  • -

    Collagen (RT-PCR, IHC)

† Re-epithelialization was accelerated in both normal and diabetic neutropenic mice.