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. 2022 Feb 23;23(5):2444. doi: 10.3390/ijms23052444

Table 3.

Summary of data from macrophage depletion papers.

Study Wound Type Targeting
Method		 Key Results
Mirza (2009) [53] Excisional Genetic
(CD11b-DTR)		 No change:
  • -

    Neutrophils (Ly-6G)

  • -

    Monocytes (Ly-6C)

  • -

    Collagen (hydroxyproline)

  • -

    Wound disruption strength

Decrease:
  • -

    Reepithelialization (microscopic)

  • -

    Granulation tissue

  • -

    Collagen (trichrome)

  • -

    Vascularity (CD-31)

  • -

    Cellular proliferation (BrdU)
Goren (2009) [51] Excisional Genetic
(LysM-cre/DTR)		 Increase:
  • -

    Wound size (microscopic)

  • -

    Neutrophils (Gr-1)

Decrease:
  • -

    Contraction (microscopic)

  • -

    Vascularity (CD-31)

  • -

    Myofibroblasts (αSMA)
Lucas (2010) [52] Excisional Genetic
(LysM-cre/iDTR)		 Increase:
  • -

    Wound size (macroscopic)

Decrease:
  • -

    Epithelial closure (microscopic)

  • -

    Panniculus carnosus contraction (microscopic)

  • -

    Granulation tissue

  • -

    Scar formation (picrosirius red)

  • -

    Vascularity (CD-31)

  • -

    Myofibroblasts (α-SMA)

No change:
  • -

    Neutrophils (Gr-1)
Shook (2016) [54] Excisional Genetic
(LysM-cre/iDTR;
Mgl2DTR/GFP †)		 Decrease:
  • -

    Reepithelialization (microscopic)

  • -

    Proliferation (phospho-histone H3)

  • -

    Fibroblasts (ER-TR7)

  • -

    Vascularity (CD-31)

  • -

    Myofibroblasts (α-SMA) #

† Mgl2DTR/GFP mice lack CD301b+ cells. # shown for Mgl2DTR/GFP mice only.