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. 2022 Feb 23;23(5):2444. doi: 10.3390/ijms23052444

Table 4.

Summary of data from T cell depletion papers.

Study Wound Type Targeting
Method		 Key Results
Pan T cell depletion
Peterson (1987) [62] Incisional +
PVA sponge		 Antibody
(anti-Thy1.2)		 Decrease:
  • -

    Wound breaking strength

  • -

    Collagen (hydroxyproline) *
Barbul (1989) [65] Incisional +
PVA sponge		 Genetic
(Foxn1nu)		 Increase:
  • -

    Wound breaking strength

  • -

    Collagen (hydroxyproline) *
Efron (1990) [63] Incisional +
PVA sponge		 Antibody
(anti-Thy1.2)		 Decrease:
  • -

    Wound breaking strength

  • -

    Collagen (hydroxyproline) *
Gawronska-Kozak (2006) [66] Incisional Genetic
(Foxn1nu) 		Decrease:
  • -

    Scar formation (trichrome)

  • -

    Collagen (hydroxyproline)
αβ T cell depletion
Barbul (1989) [68] Incisional +
PVA sponge		 Antibody
(anti-CD4)		 No change:
  • -

    Wound breaking strength

  • -

    Collagen (hydroxyproline) *
Antibody
(anti-CD8)		 Increase:
  • -

    Wound breaking strength

  • -

    Collagen (hydroxyproline) *
Efron (1990) [63] Incisional +
PVA sponge		 Antibody
(anti-CD4 + anti-CD8)		 Increase:
  • -

    Wound breaking strength

  • -

    Collagen (hydroxyproline) *
Davis (2001) [69] Incisional + thymectomy Antibody
(anti-CD4) 		Decrease:
  • -

    Wound breaking strength
Antibody
(anti-CD8)		 Increase:
  • -

    Wound breaking strength
Antibody
(anti-CD4 + anti-CD8)		 No change:
  • -

    Wound breaking strength
Chen (2014) [64] Excisional Genetic
(CD4−/−) 		No change:
  • -

    Wound closure (macroscopic)

  • -

    Keratinocyte proliferation (Ki-67)

  • -

    Wound breaking strength

  • -

    Collagen (hydroxyproline)

  • -

    Vascularity (CD-31)

Increase:
  • -

    CD8 T cells
Genetic
(CD8−/−)		 No change:
  • -

    Wound closure (macroscopic)

  • -

    Keratinocyte proliferation (Ki-67)

  • -

    Wound breaking strength

  • -

    Collagen (hydroxyproline)

  • -

    Vascularity (CD-31)

Decrease:
  • -

    CD4 T cells

  • -

    Neutrophils (Gr-1)

  • -

    Macrophages (CD68)
Treg depletion
Nosbaum (2016) [71] Excisional Genetic
(Foxp3-DTR)		 Decrease:
  • -

    Wound closure (macroscopic)

Increase:
  • -

    Proinflammatory macrophages (Ly-6Chi)

  • -

    CD4 and CD8 T cells

Haertel (2018) [70] Excisional Genetic
(Foxp3-DTR-eGFP)		 Decrease:
  • -

    Wound closure (microscopic)

  • -

    Reepithelialization (microscopic)

  • -

    Contraction (microscopic)

Increase:
  • -

    αβ T cells

γδ T cell depletion
Jameson (2002) [80] Excisional Genetic
(TCRδ−/−)		 Decrease:
  • -

    Wound closure (macroscopic)

  • -

    Keratinocyte proliferation (BrdU)

* Measured in PVA sponge.