Table 3.
Hyper-proliferation and carcinogenesis in 850 MIN COL model.
| Marker | Cellular Models | |||
|---|---|---|---|---|
| C57 COL | 850 MIN COL | p Value | Relative to C57 COL |
|
| PDT (h.) a | 34.0 ± 3.8 | 14.0 ± 1.6 | 0.032 | −58.9% |
| Sat. Den. (×105) b | 7.7 ± 0.5 | 67.9 ± 7.5 | 0.001 | +7.8x |
| G1: S + G2/M c | 3.1 ± 0.3 | 0.6 ± 0.2 | 0.010 | −80.0% |
| Aneuploidy (%) c | Not detected | 81.7 ± 9.1 | ||
| Sub G0 (%) c | 4.3 ± 0.1 | 0.8 ± 0.3 | 0.010 | −81.4% |
| AI Colonies d | ||||
| Incidence | 0/18 | 18/18 | ||
| Number | ---- | 18.9 ± 2.5 | ||
| Tumor | ||||
| Incidence | 0/10 | 8/10 | ||
| Latency | 24 weeks | 3–5 weeks | ||
a determined from exponential growth phase. b determined at day seven after seeding 1.0 × 105 cells. c determined at day four after seeding 1 × 105 cells by cell cycle analysis. d determined at day 14 after seeding 100 cells. Data presented as mean ± SD, n = 3 per treatment group, and analyzed by Student’s t-test. PDT, population doubling time; Sat. Den., saturation density; AI, anchorage independent; SD, standard deviation. Data are summarized from [21].