Table 1.
GO analysis of DEGs associated with PAs.
| a, BP | |||
|---|---|---|---|
| GO Term | Function | Count | p-Value |
| GO:0042445 | Hormone metabolic process | 6 | 9.61 × 10−5 |
| GO:0010817 | Regulation of hormone levels | 6 | 5 × 10−4 |
| GO:0045893 | Regulation of transcription, DNA-dependent | 8 | 0.004535 |
| GO:0051254 | Positive regulation of RNA metabolic process | 8 | 0.004745 |
| GO:0009725 | Response to hormone stimulus | 7 | 0.005137 |
| GO:0003006 | Reproductive developmental process | 6 | 0.005603 |
| GO:0009719 | Response to endogenous stimulus | 7 | 0.008202 |
| GO:0045665 | Negative regulation of neuron differentiation | 3 | 0.009053 |
| GO:0031667 | Response to nutrient levels | 5 | 0.010641 |
| GO:0045941 | Positive regulation of transcription | 8 | 0.011004 |
| GO:0060541 | Respiratory system development | 4 | 0.011637 |
| GO:0021510 | Spinal cord development | 3 | 0.012494 |
| GO:0010033 | Response to organic substance | 9 | 0.012515 |
| GO:0010628 | Positive regulation of gene expression | 8 | 0.012807 |
| GO:0006357 | Regulation of transcription from RNA polymerase | 9 | 0.013109 |
| GO:0001503 | Ossification | 4 | 0.013776 |
| GO:0035295 | Tube development | 5 | 0.015426 |
| GO:0009991 | Response to extracellular stimulus | 5 | 0.015426 |
| GO:0060348 | Bone development | 4 | 0.016477 |
| GO:0048608 | Reproductive structure development | 4 | 0.017561 |
| GO:0045935 | Regulation of nucleic acid metabolic process | 8 | 0.018314 |
| GO:0002684 | Positive regulation of immune system process | 5 | 0.01999 |
| GO:0048732 | Gland development | 4 | 0.021049 |
| GO:0051173 | Regulation of nitrogen compound metabolic | 8 | 0.021377 |
| GO:0010001 | Glial cell differentiation | 3 | 0.022349 |
| GO:0045944 | Regulation of transcription from RNA polymerase | 6 | 0.022552 |
| GO:0010557 | Regulation of macromolecule biosynthetic | 8 | 0.023036 |
| GO:0006590 | Thyroid hormone generation | 2 | 0.025889 |
| GO:0007548 | Sex differentiation | 4 | 0.028124 |
| GO:0031328 | Positive regulation of cellular biosynthetic | 8 | 0.028748 |
| GO:0009891 | Positive regulation of biosynthetic process | 8 | 0.03078 |
| GO:0010558 | Regulation of macromolecule biosynthetic | 7 | 0.031329 |
| GO:0048754 | Branching morphogenesis of a tube | 3 | 0.032633 |
| GO:0042063 | Gliogenesis | 3 | 0.032633 |
| GO:0031327 | Negative regulation of cellular biosynthetic | 7 | 0.034828 |
| GO:0035270 | Endocrine system development | 3 | 0.036402 |
| GO:0009890 | Negative regulation of biosynthetic process | 7 | 0.038022 |
| GO:0001763 | Morphogenesis of a branching structure | 3 | 0.041338 |
| GO:0030182 | Neuron differentiation | 6 | 0.041736 |
| GO:0006766 | ViTamoxifenin metabolic process | 3 | 0.042354 |
| GO:0030522 | Intracellular receptor-mediated signaling pathway | 3 | 0.042354 |
| GO:0048598 | Embryonic morphogenesis | 5 | 0.044701 |
| GO:0030278 | Regulation of ossification | 3 | 0.045457 |
| GO:0040007 | Growth | 4 | 0.0456 |
| GO:0034097 | Response to cytokine stimulus | 3 | 0.04651 |
| GO:0046457 | Prostanoid biosynthetic process | 2 | 0.046959 |
| GO:0001516 | Prostaglandin biosynthetic process | 2 | 0.046959 |
| GO:0016481 | Negative regulation of transcription | 6 | 0.049316 |
| b, CC | |||
| GO term | Function | Count | p-value |
| GO:0044421 | Extracellular region part | 16 | 5.93 × 10−5 |
| GO:0005576 | Extracellular region | 22 | 5.27 × 10−4 |
| GO:0005578 | Proteinaceous extracellular matrix | 8 | 0.001055 |
| GO:0031012 | Extracellular matrix | 8 | 0.001628 |
| GO:0005615 | Extracellular space | 10 | 0.006775 |
| c, MF | |||
| GO term | Function | Count | p-value |
| GO:0005201 | Extracellular matrix structural constituent | 4 | 0.006984 |
| GO:0005506 | Iron ion binding | 6 | 0.012809 |
| GO:0005509 | Calcium ion binding | 10 | 0.022046 |
GO: gene ontology; DEGs: differentially expressed genes; PAs: pituitary adenomas; BP: biological process; MF: molecular function; CC: cellular component.