Table 1.
Summary of experimental studies targeting various antigens.
| Target | Model | Result | Reference |
|---|---|---|---|
| apoB | hypercholesterolemic huB100(tg) × Ldlr–/– mice | Inhibition of atherosclerosis through the activation of Tregs | [53] |
| apoB | ApoE–/– | Inhibition of atherosclerosis through the activation of Tregs | [55] |
| PCSK9 | BALB/c mice | Induction of humoral immune response against PCSK9 | [56] |
| mbHSP65 | ApoE–/– mice | Lesion size decrease | [57] |
| HSP60, apoB | ApoB(tm2Sgy)/Ldlr(tm1Her/J) mice | Induced T-cell proliferation and expansion of regulatory T cells with interleukin-10 and transforming growth factor-β secretion | [58] |
| HSP60 | Six-week-old male ApoE–/– mice from a C57BL/6J background | Significant 33·6% reduction in plaque size at the aortic root in the early stages of atherosclerosis | [59] |