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. 2022 Feb 25;23(5):2548. doi: 10.3390/ijms23052548
Abcc6 ATP binding cassette subtype C number 6
ABE Adenine base editor
Abhd6 Alpha/beta-hydrolase domain 6
Adora2a Adenosine 2a receptor
α-Gal A α-galactosidase A
Agxt Alanine-glyoxylate aminotransferase
Ahr Aryl hydrocarbon receptor
Aire Autoimmune regulator
ALS Amyotrophic lateral sclerosis
Angptl8 Angiopoietin-like protein 8
Anks3 Ankyrin repeat and sterile alpha motif domain containing 3
APECED Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
ApoE Apolipoprotein E
AS Angelman syndrome
AsCpf1 Acidaminococcus sp. Cpf1
ASD Autism spectrum disorder
Asip Agouti signaling protein
Atg16l1 Autophagy-related 16-like 1
B2m Beta-2-microglobulin
BE Base-editing
BlatCas9 Brevibacillus laterosporus Cas9
Bmpr2 Bone morphogenetic protein receptor 2
BN Brown Norway
C3 Complement C3
C9orf72 Chromosome 9 open reading frame 72
Cas12a CRISPR-associated protein 12a
Calb2 Calbindin 2
Carns1 Carnosine synthase 1
Cas9n Cas9 nickase
CBE Cytosine base editor
Ccdc85c Coiled-coil domain containing 85C
Cck Cholecystokinin
CD Crohn’s disease
CES2 Carboxylesterase 2
Ces2a Carboxylesterase 2A
CF Cystic fibrosis
Cftr Cystic fibrosis transmembrane conductance regulator
CIPN Chemotherapy-induced peripheral neuropathy
Cirp Cold-inducible RNA-binding protein
CLICK CRISPR with lssDNA inducing conditional knockout alleles
Cp Ceruloplasmin
Cpf1 CRISPR from Prevotella and Francisella1
Cplx1 Complexin I
Cre-ERT2 Cre recombinase-estrogen receptor T2
Crhr1 Corticotropin releasing hormone receptor 1
CRISPR/Cas9 Clustered regularly interspaced palindrome repeats (CRISPR)/Caspase 9 (Cas9)
Cas12a Type V CRISPR-effector protein (formerly Cpf1)
crRNA CRISPR RNA
CS Cockayne syndrome
Csb Cockayne syndrome B
Cyp2c11 Cytochrome P450, subfamily 2, polypeptide 11
Cyp2d Cytochrome P450 family 2 subfamily D member 6
Cyp2e1 Cytochrome P450 2E1
Cyp2J2 Cytochrome P450 family 2 subfamily J member 2
Cyp2J3 Cytochrome P450, family 2, subfamily j, polypeptide 3
Cyp2J10 Cytochrome P450, family 2, subfamily j, polypeptide 10
Cyp3a1 Cytochrome P450 3A1
Cyp3a2 Cytochrome P450 3A2
Cyp24a1 Cytochrome P450 family 24 subfamily A member 1
Cyp27b1 Cytochrome P450 family 27 subfamily B member 1
DA Dark agouti
Dat Dopamine transporter
db Diabetes
Dbndd1 Dysbindin (dystrobrevin binding protein 1) domain containing 1
Defb23 Defensin beta 23
Defb26 Defensin beta 26
Defb42 Defensin beta 42
dCas9 Dead Cas9
DdCBE DddA-derived cytosine base editor
DddA Bacterial toxin deaminase
Depdc5 DEP domain-containing 5
Des Desmin
DdCBE DddA-derived cytosine base editor
DMD Duchenne muscular dystrophy
Dmd Dystrophin-coding gene (dystrophin)
DKO Double KO
DNA-PKcs DNA-dependent protein kinase catalytic subunits
Dnah17 Dynein axonemal heavy chain 17
Drd1a Dopamine receptor D1A
DSB Double-stranded break
dsDNA Double-stranded DNA
dsRed Discosoma coral red fluorescent protein
EGFP Enhanced green fluorescent protein
EndoMT Endothelial-to-mesenchymal transition
EP Electroporation
Epsti1 Epithelial stromal interaction 1
Erbb3 Erb-B2 receptor tyrosine kinase 3
ERV Endogenous retroviral element
ES Embryonic stem
Esr1 Estrogen receptor 1
ET Egg transfer
F344 Fisher 344
F8 Factor 8
Fabp2 Fatty acid binding protein 2
Fah Fumarylacetoacetate hydrolase
FD Fabry disease
Fh Fumarate hydratase
FH Familial hypercholesterolemia
FHH Fawn-hooded hypertensive
Fmr1 Fragile X mental retardation 1
FMRP Fragile X mental retardation protein
FnCas9 Francisella novicida Cas9
Foxp3 Forkhead box P3
Foxn1 Forkhead box N1
FSG F344-scid gamma
Fus Fused in sarcoma
FXS Fragile X syndrome
Gaa Acid alpha-glucosidase
Gad1 Glutamate decarboxylase 1
GAD67 Glutamate decarboxylase 67-kDa isoform
GE Genome editing or genome-edited
GFP Green fluorescent protein
G6pd Glucose-6-phosphate dehydrogenase
GM Genetically modified
GOI Gene of interest
GONAD Genome-editing via oviductal nucleic acids delivery
GR Glucocorticoid receptors
GRdim Glucocorticoid receptor mutant
Grin1 Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 1
gRNA Guide RNA
Gsd2 Glycogen storage disease type 2
GSDII Glycogen storage disease type II (GSDII)
2H2OP Two-hit by gRNA and two-oligo with plasmid
HA Hereditary aceruloplasminemia
HCD High-cholesterol diet
HDR Homology directed repair
Hemgn Hemogen
hhy Hemorrhagic hydrocephalus
Hprt1 Hypoxanthine phosphoribosyltransferase 1
HR Homologous recombination
HT1 Hereditary tyrosinemia type I
Htr7 5-hydroxytryptamine receptor 7
IC Intracytoplasmic injection
Ighm Immunoglobulin heavy constant mu
IgM Immunoglobulin M
i-GONAD Improved GONAD
Il2rg Interleukin 2 receptor gamma
indels Insertion or deletion of nucleotides
iNOS Inducible nitric oxide synthase
IRES Internal ribosomal entry site
IVF In vitro fertilized
Kat II Kynurenine aminotransferase II
Kcnj16 Potassium inwardly-rectifying channel, subfamily J, member 16
Kcnk3 Potassium channel subfamily K member 3
KI Knock-in
Kit Kit proto-oncogene
KO Knockout
L1cam L1 cell adhesion molecule
LbCpf1 Lachnospiraceae bacterium Cpf1
L dlr Low-density lipoprotein receptor
Lrat Lecithin retinol acyltransferase
Lepr Leptin receptor
LE Long–Evans
LEH Long–Evans hooded
Lepr Leptin receptor
LEW Lewis
Lgr5 Leucine-rich repeat-containing G-protein coupled receptor 5
lncRNA Long non-coding RNA
Lrat Lecithin retinol acyltransferase
lssDNA Long single-stranded DNA
Mc3r Melanocortin 3 receptor
Mc4r Melanocortin 4 receptor
Mdr1a Multidrug resistance protein 1a
Mdr1b Multidrug resistance protein 1b
Mdx X-linked muscular dystrophy
Mecp2 Methyl-CpG-binding protein 2
MI Microinjection
mitoTALE TALE nickase enabling mitochondrial gene editing
Mkx Mohawk homeobox
Mnx1 Gene encoding homeobox protein HB9
mtDNA Mitochondrial DNA
mTORC1 Rapamycin complex 1 signaling pathway
Myl4 Myosin light-chain 4
NAFLD Nonalcoholic fatty liver disease
nCas9 Cas9 nickase
Ndst1 N-deacetylase
Ndst4 N-sulfotransferase 4
Nes Nestin
Nfatc1 Nuclear factor of activated T-cells
Ngln3 Neuroligin 3
NHEJ Non-homologous end joining
Nkx3.1 NK3 homeobox 1
NmCas9 Neisseria meningitidis Cas9
Nr3c1 Nuclear receptor subfamily 3, group C, member 1
Nrf2 Nuclear factor (erythroid-derived 2)-like-2
Oatp1b2 Organic anion transport polypeptide 1b2
Ogdh Oxoglutarate dehydrogenase
PAH Pulmonary arterial hypertension
PAM Protospacer adjacent motif
PB PiggyBack transposon
PBS Phosphate-buffered saline
PE Prime editing
PGK Phosphoglycerate kinase
PH Pulmonary hypertension
PH1 Primary hyperoxaluria type 1
PI Pronuclear injection
PMCA4 Plasma membrane calmodulin–dependent calcium ATPase isoform 4
PMS Phelan–McDermid syndrome
Pnpla5 Patatin-like phospholipase domain containing 5
poly(A) Polyadenine tails
Pomc Proopiomelanocortin
Pp Poring pulse
PPi Pyrophosphate
Prf1 Perforin 1
Prkdc DNA-dependent protein kinase catalytic subunit
Psen1 Presenilin 1
p52SHC/p46SHC Adaptor protein 1 (shc1), encodes 3 main protein isoforms
Pvalb Parvalbumin
PVG Piebald Virol Glaxo
PXE Pseudoxanthoma elasticum
Pxr Pregnane X receptor
rAAV Recombinant adeno-associated virus
Rab38 Ras-related protein Rab-38
Rag1 Recombination activating gene 1
Rag2 Recombination activating gene 2
RD Retinal dystrophy
R en Renin
Rffl-lnc1 A gene located within the 5′UTR intronic region of the rififylin (Rffl) gene
rGONAD Rat-based i-GONAD
RNaseT2 Ribonuclease T2
RNP Ribonucleoprotein
Rosa26 Gt(ROSA)26Sor
RP Retinitis pigmentosa
RS Rett syndrome
SaCas9 Staphylococcus aureus Cas9
SCID Severe combined immunodeficiency
SD Sprague–Dawley
SERCA2a Sarcoplasmic reticulum Ca2+-ATPase
sgRNA Single-guide RNA
Shank3 SH3 and multiple ankyrin repeat domains 3
Sirpa Signal regulatory protein alpha
Slc6 Sodium- and chloride-dependent members of the solute carrier family 6
Slc16a2 Solute carrier family 16 member 2 coding for monocarboxylate transporter 8 (MCT8)
Slco1b2 Solute carrier organic anion transporter family member 1B2
SNP Single-nucleotide polymorphism
Sox10 Sry-box transcription factor 10
Sox16 SRY (sex determining region Y)-box 16
SS Dahl salt-sensitive
SSCs Spermatogonial stem cells
ssDNA Single-stranded DNA
ssODN Single-stranded oligodeoxynucleotide
St1Cas9 Streptococcus thermophilus Cas9
STs Seminiferous tubules
TAKE Technique for Animal Knockout system by Electroporation
TALE Transcriptional activator-like effector
TALENs Transcription activator-like effector nucleases
Tet1 Tet methylcytosine dioxygenase 1
Tet2 Tet methylcytosine dioxygenase 2
Tet3 Tet methylcytosine dioxygenase 3
Tg Transgenic
Th Tyrosine hydroxylase
Thy1 Thy-1 cell surface antigen
Tie2 Tunica interna endothelial cell kinase 2
Tlr4 Toll-like receptor 4
TM/Kyo TRM or tremor rat
Tp Transfer pulse
Tp53 Tumor protein p53
tracrRNA Trans-activating CRISPR RNA
Trdmt1 TRNA aspartic acid methyltransferase 1
Trpa1 Transient receptor potential family member ankyrin 1
Trpv4 Transient receptor potential cation channel subfamily V member 4
Tyr Tyrosinase
Ube3a Ubiquitin protein ligase E3A
Uox Urate oxidase (uricase)
Vapb Vesicle-associated membrane protein-associated protein B/C
Vdr Vitamin D receptor
Wfs1 Wolfram syndrome 1
WI Wistar
WI-IM Wistar–Imamichi
WKY Wistar–Kyoto
Wnt1 Wnt family member 1
WS Wolfram syndrome
WT Wild-type
XLH X-linked hydrocephalus
X-SCID X-linked severe combined immunodeficiency
ZF Zinc-finger
ZFNs Zinc-finger nucleases
ZP Zona pellucida