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. 2022 Feb 25;23(5):2536. doi: 10.3390/ijms23052536

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Collagen-mediated signaling via glycoprotein (GP) VI. In addition to adhesion mediated by GPIa-IIa (integrin α2β1), collagen induces platelet activation via GPVI. It triggers the formation of IP3 releasing Ca²⁺ from internal stores. PKC isoforms also participate in further platelet activation. This figure is inspired from [138,139,140]. Legend: BTK: Bruton’s kinases; Ca²⁺: calcium; DAG: diacylglycerol; FcRγ: Fc receptor γ-chain; IP3: inositol trisphosphate; ITAM: immunoreceptor tyrosine activation motif; LAT: linker for activation of T cells; MAPK: mitogen-activated protein kinases; PI3K: phosphatidylinositide-3-kinase; PIP2: phosphatidylinositol-4,5-bisphosphate; PLCγ2: phospholipase C γ2; Rap1: Ras-related protein 1; Syk: spleen tyrosine kinase; TXA2: thromboxane A2.